Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (510 aa)    
Predicted Functional Partners:
PDE6C
Phosphodiesterase.
   
  
 0.630
ABCA4
ATP binding cassette subfamily A member 4.
      
 0.622
MERTK
MER proto-oncogene, tyrosine kinase.
      
 0.601
ROM1
Retinal outer segment membrane protein 1.
      
 0.577
GNAT2
G protein subunit alpha transducin 2.
      
 0.551
PELO
Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs.
 
      0.545
MITF
Melanocyte inducing transcription factor.
    
 
 0.512
CRYBA1
Crystallin beta A1; Belongs to the beta/gamma-crystallin family.
   
  
 0.505
GLIPR1
GLI pathogenesis related 1; Belongs to the CRISP family.
   
  
 0.495
GLUL
Glutamine synthetase.
    
 
 0.483
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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