STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)    
Predicted Functional Partners:
CHD4
Uncharacterized protein.
   
 0.979
SAP30
Sin3A associated protein 30.
    
 0.962
RCOR1
REST corepressor 1.
    
 0.959
NCOR2
Nuclear receptor corepressor 2.
    
 0.946
RB1
RB transcriptional corepressor 1.
   
 0.945
SAP30L
SAP30 like.
    
 0.941
MTA2
Metastasis associated 1 family member 2.
   
 0.940
CHD3
Chromodomain helicase DNA binding protein 3.
   
 0.936
HDAC3
Hist_deacetyl domain-containing protein.
   
 0.936
MTA1
Metastasis associated 1.
   
 0.934
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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