STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BHLHE40Basic helix-loop-helix family member e40. (412 aa)    
Predicted Functional Partners:
RFX1
Regulatory factor X1.
      
 0.723
ARNTL
Aryl hydrocarbon receptor nuclear translocator like.
    
 0.713
CRY1
Cryptochrome circadian regulator 1.
   
 
 0.639
NR1D2
Nuclear receptor subfamily 1 group D member 2.
   
 
 0.608
NR1D1
Nuclear receptor subfamily 1 group D member 1.
    
 
 0.582
PSMB2
Proteasome subunit beta.
    
 
 0.581
RORA
RAR related orphan receptor A.
    
 
 0.529
RORB
RAR related orphan receptor B.
    
 
 0.513
CRY2
Cryptochrome circadian regulator 2.
   
 
 0.511
NFIL3
Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]
    
 0.496
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.