Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
RPS6KA1Non-specific serine/threonine protein kinase. (703 aa)    
Predicted Functional Partners:
RPS6KA3
Ribosomal protein S6 kinase.
   
  0.999
RPS6KA2
Ribosomal protein S6 kinase.
   
  0.998
TSC2
TSC complex subunit 2.
   
 0.967
RPS6KA6
Non-specific serine/threonine protein kinase.
   
 
  0.966
MAPK1
Mitogen-activated protein kinase.
   
 0.949
MAPK3
Mitogen-activated protein kinase.
   
 0.949
CREB1
cAMP responsive element binding protein 1.
   
 0.947
TSC1
TSC complex subunit 1.
    
 0.937
MAPK7
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.919
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 
 0.911
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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