STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (433 aa)    
Predicted Functional Partners:
TMPRSS2
Transmembrane serine protease 2; Belongs to the peptidase S1 family.
  
0.954
TMPRSS11F
Transmembrane protease serine; Belongs to the peptidase S1 family.
  
 
0.797
TMPRSS13
Transmembrane serine protease 13; Belongs to the peptidase S1 family.
   
 0.638
PRSS8
Uncharacterized protein; Belongs to the peptidase S1 family.
  
0.614
F11
Coagulation factor XI; Belongs to the peptidase S1 family.
  
0.612
TMPRSS11A
Transmembrane serine protease 11A; Belongs to the peptidase S1 family.
  
 
0.595
TOP3B
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
      
 0.573
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
   
 
 0.570
TMPRSS11D
Transmembrane protease serine; Belongs to the peptidase S1 family.
  
 
0.565
G3U604_LOXAF
Transmembrane protease serine; Belongs to the peptidase S1 family.
  
 
0.563
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.