RIC8B protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

RIC8B

RIC8 guanine nucleotide exchange factor B. (560 aa)

Predicted Functional Partners:

RTP1

0.828

GNAL

0.768

G3UF61_LOXAF

0.768

RTP2

0.731

ALDH18A1

0.602

TCEANC2

0.591

CHRM5

0.589

CHRM4

0.589

LRRC42

0.585

SMIM15

0.583

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH18A1	RIC8B	ENSLAFP00000013424	ENSLAFP00000004192	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	RIC8 guanine nucleotide exchange factor B.	0.602
CHRM4	CHRM5	ENSLAFP00000027437	ENSLAFP00000020668	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.650
CHRM4	G3UF61_LOXAF	ENSLAFP00000027437	ENSLAFP00000026469	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Uncharacterized protein.	0.405
CHRM4	GNAL	ENSLAFP00000027437	ENSLAFP00000006609	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha L.	0.405
CHRM4	RIC8B	ENSLAFP00000027437	ENSLAFP00000004192	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	RIC8 guanine nucleotide exchange factor B.	0.589
CHRM4	RTP1	ENSLAFP00000027437	ENSLAFP00000017074	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Receptor transporter protein 1.	0.585
CHRM4	RTP2	ENSLAFP00000027437	ENSLAFP00000021775	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Receptor transporter protein 2.	0.588
CHRM5	CHRM4	ENSLAFP00000020668	ENSLAFP00000027437	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.650
CHRM5	G3UF61_LOXAF	ENSLAFP00000020668	ENSLAFP00000026469	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Uncharacterized protein.	0.663
CHRM5	GNAL	ENSLAFP00000020668	ENSLAFP00000006609	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha L.	0.663
CHRM5	RIC8B	ENSLAFP00000020668	ENSLAFP00000004192	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	RIC8 guanine nucleotide exchange factor B.	0.589
CHRM5	RTP1	ENSLAFP00000020668	ENSLAFP00000017074	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Receptor transporter protein 1.	0.574
CHRM5	RTP2	ENSLAFP00000020668	ENSLAFP00000021775	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Receptor transporter protein 2.	0.577
G3UF61_LOXAF	CHRM4	ENSLAFP00000026469	ENSLAFP00000027437	Uncharacterized protein.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.405
G3UF61_LOXAF	CHRM5	ENSLAFP00000026469	ENSLAFP00000020668	Uncharacterized protein.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.663
G3UF61_LOXAF	GNAL	ENSLAFP00000026469	ENSLAFP00000006609	Uncharacterized protein.	G protein subunit alpha L.	0.886
G3UF61_LOXAF	RIC8B	ENSLAFP00000026469	ENSLAFP00000004192	Uncharacterized protein.	RIC8 guanine nucleotide exchange factor B.	0.768
GNAL	CHRM4	ENSLAFP00000006609	ENSLAFP00000027437	G protein subunit alpha L.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.405
GNAL	CHRM5	ENSLAFP00000006609	ENSLAFP00000020668	G protein subunit alpha L.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.663
GNAL	G3UF61_LOXAF	ENSLAFP00000006609	ENSLAFP00000026469	G protein subunit alpha L.	Uncharacterized protein.	0.886

page 1 of 3

Server load: low (8%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About