MAP2K7 protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MAP2K7

Mitogen-activated protein kinase kinase 7. (497 aa)

Predicted Functional Partners:

MAPK9

0.983

MAPK10

0.981

MAPK8

0.981

MAP3K1

0.979

MAPK8IP1

0.978

MAP2K4

0.973

MAP3K7

0.972

MAPK8IP2

0.971

MAP3K20

0.970

MAPK8IP3

0.960

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAP2K4	MAP2K7	ENSLAFP00000011256	ENSLAFP00000004194	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 7.	0.973
MAP2K4	MAP3K1	ENSLAFP00000011256	ENSLAFP00000000827	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 1.	0.991
MAP2K4	MAP3K20	ENSLAFP00000011256	ENSLAFP00000014373	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.817
MAP2K4	MAP3K7	ENSLAFP00000011256	ENSLAFP00000015626	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.994
MAP2K4	MAPK10	ENSLAFP00000011256	ENSLAFP00000010097	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.992
MAP2K4	MAPK8	ENSLAFP00000011256	ENSLAFP00000024645	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.993
MAP2K4	MAPK8IP3	ENSLAFP00000011256	ENSLAFP00000026385	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 8 interacting protein 3.	0.936
MAP2K4	MAPK9	ENSLAFP00000011256	ENSLAFP00000026560	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.996
MAP2K7	MAP2K4	ENSLAFP00000004194	ENSLAFP00000011256	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.973
MAP2K7	MAP3K1	ENSLAFP00000004194	ENSLAFP00000000827	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase 1.	0.979
MAP2K7	MAP3K20	ENSLAFP00000004194	ENSLAFP00000014373	Mitogen-activated protein kinase kinase 7.	Protein kinase domain-containing protein.	0.970
MAP2K7	MAP3K7	ENSLAFP00000004194	ENSLAFP00000015626	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.972
MAP2K7	MAPK10	ENSLAFP00000004194	ENSLAFP00000010097	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase.	0.981
MAP2K7	MAPK8	ENSLAFP00000004194	ENSLAFP00000024645	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase.	0.981
MAP2K7	MAPK8IP1	ENSLAFP00000004194	ENSLAFP00000021392	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase 8 interacting protein 1.	0.978
MAP2K7	MAPK8IP2	ENSLAFP00000004194	ENSLAFP00000015058	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase 8 interacting protein 2.	0.971
MAP2K7	MAPK8IP3	ENSLAFP00000004194	ENSLAFP00000026385	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase 8 interacting protein 3.	0.960
MAP2K7	MAPK9	ENSLAFP00000004194	ENSLAFP00000026560	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase.	0.983
MAP3K1	MAP2K4	ENSLAFP00000000827	ENSLAFP00000011256	Mitogen-activated protein kinase kinase kinase 1.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.991
MAP3K1	MAP2K7	ENSLAFP00000000827	ENSLAFP00000004194	Mitogen-activated protein kinase kinase kinase 1.	Mitogen-activated protein kinase kinase 7.	0.979

page 1 of 4

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 113

1.62

3.77

3.55e-15

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019843

rRNA binding

10 of 45

1.98

5.81

5.54e-17

GO:0003735

Structural constituent of ribosome

11 of 57

1.92

5.8

1.87e-18

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 60

1.89

5.77

5.36e-19

GO:0044391

Ribosomal subunit

4 of 15

2.06

2.8

1.33e-06

GO:0015934

Large ribosomal subunit

3 of 9

2.15

2.26

3.34e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:149

Structural constituent of ribosome

11 of 53

1.95

6.0

1.32e-18

CL:152

Structural constituent of ribosome

8 of 30

2.06

5.29

9.21e-14

CL:153

Structural constituent of ribosome

7 of 20

2.17

5.22

1.75e-12

CL:155

rRNA-binding

6 of 15

2.23

4.69

9.52e-11

CL:175

rRNA-binding

3 of 5

2.41

2.39

2.90e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lmoi03010

Ribosome

11 of 58

1.91

5.89

3.55e-19

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

6 of 42

1.78

2.96

3.80e-08

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 127

1.37

1.91

3.06e-07

GOCC:0044391

Ribosomal subunit

3 of 16

1.9

1.63

0.00047

GOCC:0043229

Intracellular organelle

11 of 419

1.05

1.38

1.04e-09

GOCC:0015934

Large ribosomal subunit

2 of 8

2.03

1.11

0.0077

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0699

rRNA-binding

10 of 41

2.02

6.22

6.53e-18

KW-0689

Ribosomal protein

11 of 59

1.9

5.79

7.13e-19

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About