STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)    
Predicted Functional Partners:
NLRP3
NLR family pyrin domain containing 3.
    
 0.971
NEK9
NIMA related kinase 9.
    
0.885
G3U5M8_LOXAF
Uncharacterized protein.
 
  
 0.847
G3TBG8_LOXAF
Uncharacterized protein.
 
  
 0.844
GSDMD
Gasdermin D.
      
 0.644
ANKS3
Ankyrin repeat and sterile alpha motif domain containing 3.
    
 
 0.604
ANKS6
Ankyrin repeat and sterile alpha motif domain containing 6.
    
 
 0.546
IL18
Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.
      
 0.506
CDC27
Cell division cycle 27.
   
 0.498
RCC1L
RCC1 like.
    
 0.492
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.