Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MDH2Malate dehydrogenase. (338 aa)    
Predicted Functional Partners:
GOT2
Aspartate aminotransferase.
   
 0.998
CS
Citrate synthase; Belongs to the citrate synthase family.
  
 0.994
ATP5F1A
ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 0.990
ACO2
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.985
ATP5F1B
ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 0.985
FH
Fumarate hydratase.
  
 0.982
SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  
 0.978
MDH1
Malate dehydrogenase.
   
 0.975
SUCLG1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
 0.972
GOT1
Aspartate aminotransferase.
   
 0.968
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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