STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)    
Predicted Functional Partners:
RHO
Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
   
 0.973
RCVRN
Recoverin.
   
 0.960
GRK1
G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
   
  0.903
SAG
S-antigen visual arrestin.
   
 0.901
ARRB2
Arrestin beta 2.
   
 0.887
CCR9
C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.
    
 0.880
CXCR6
C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.
    
 0.880
CXCR4
C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.
    
 0.879
CCR3
C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.
    
  0.873
CCR7
C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.
    
  0.873
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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