STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CPECarboxypeptidase E. (476 aa)    
Predicted Functional Partners:
GAK
Cyclin G associated kinase.
    
  0.948
CPB2
Carboxypeptidase B2.
  
  
 0.899
PCSK2
Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.
   
  
 0.695
POMC
Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family.
      
 0.656
GNRH1
Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.
      
 0.621
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
     
 0.591
PCSK1
Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.
   
  
 0.537
CHGA
Chromogranin A.
      
 0.523
PCSK1N
Proprotein convertase subtilisin/kexin type 1 inhibitor.
      
 0.523
PEX11B
Peroxisomal biogenesis factor 11 beta.
      
 0.520
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.