Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
XPNPEP2X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. (677 aa)    
Predicted Functional Partners:
MEP1B
Meprin A subunit.
   
 
 0.924
MEP1A
Meprin A subunit.
   
 
 0.916
DPP4
Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.
   
 
 0.895
PRCP
Prolylcarboxypeptidase.
   
 
 0.891
MME
Membrane metalloendopeptidase.
   
 
 0.891
ACE2
Angiotensin-converting enzyme.
   
 
 0.824
CLTRN
Collectrin domain-containing protein.
   
 
 0.824
ATP1B1
Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.
   
  
 0.815
SLC2A2
Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
   
  
 0.813
EVA1B
Eva-1 homolog B.
      
 0.795
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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