STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLK1Serine/threonine-protein kinase PLK. (603 aa)    
Predicted Functional Partners:
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
0.999
CCNB2
Cyclin B2; Belongs to the cyclin family.
   
 0.989
CCNB1
Cyclin B1; Belongs to the cyclin family.
   
 0.989
FBXO43
F-box protein 43.
   
 0.986
BUB1B
Uncharacterized protein.
   
 0.984
PKMYT1
Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily.
   
0.981
PLK4
Polo like kinase 4.
   
0.980
CDC25A
Cell division cycle 25A.
   
 0.978
CDC20B
Cell division cycle 20B.
   
 0.976
ESPL1
Extra spindle pole bodies like 1, separase.
   
 0.976
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.