Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TGOLN2Uncharacterized protein. (303 aa)    
Predicted Functional Partners:
AP2M1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 0.873
VAMP4
Vesicle associated membrane protein 4.
   
 0.833
GALNT2
Polypeptide N-acetylgalactosaminyltransferase.
    
 0.780
AP2S1
Clat_adaptor_s domain-containing protein.
    
  0.771
IGF2R
Insulin like growth factor 2 receptor.
   
 0.717
GCC1
GRIP and coiled-coil domain containing 1.
     
 0.702
AP2B1
AP complex subunit beta.
    
  0.670
AP1B1
AP complex subunit beta.
    
  0.670
EDEM3
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
    
   0.665
GOLGA1
Golgin A1.
    
 0.621
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (18%) [HD]