Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2617 aa)    
Predicted Functional Partners:
BIRC6
Baculoviral IAP repeat containing 6.
   
 
 0.878
ZRANB1
Zinc finger RANBP2-type containing 1.
   
 
 0.823
ZNF622
Zinc finger protein 622.
    
 
 0.805
COPA
Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
   
   0.791
SMC2
Structural maintenance of chromosomes protein.
   
   0.781
UBR3
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
  
 0.768
SMC4
Structural maintenance of chromosomes protein.
   
   0.767
TRIP12
Thyroid hormone receptor interactor 12.
   
 
 0.763
LOC100663049
VLIG-type G domain-containing protein.
    
   0.684
URGCP
Upregulator of cell proliferation.
    
   0.684
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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