STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)    
Predicted Functional Partners:
CD40
CD40 molecule.
    
 0.986
ICOS
Inducible T cell costimulator.
   
 
 0.964
FASLG
Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family.
   
 
 0.910
G3TWQ7_LOXAF
Uncharacterized protein.
     
 0.879
TNFRSF14
Uncharacterized protein.
    
 0.849
CD4
CD4 molecule.
   
  
 0.843
TNFRSF6B
TNF receptor superfamily member 6b.
     
  0.812
TNFSF13B
TNF superfamily member 13b; Belongs to the tumor necrosis factor family.
     
 0.793
BCL6
BCL6 transcription repressor.
    
 
 0.779
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.761
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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