Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FRKTyrosine-protein kinase. (516 aa)    
Predicted Functional Partners:
G3T7Q2_LOXAF
Uncharacterized protein.
   
    0.953
MST1R
Macrophage stimulating 1 receptor.
   
  0.932
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
    
 0.838
G3TRR6_LOXAF
Uncharacterized protein.
    
 0.838
EGFR
Receptor protein-tyrosine kinase.
    
 0.828
BNIP2
BCL2 interacting protein 2.
    
  0.821
KIAA1328
Uncharacterized protein.
   
    0.803
SH2D1A
SH2 domain containing 1A.
  
 0.778
RAPGEF1
Rap guanine nucleotide exchange factor 1.
   
 0.650
UGP2
UTP--glucose-1-phosphate uridylyltransferase.
    
 0.643
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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