Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
APTXAprataxin. (344 aa)    
Predicted Functional Partners:
XRCC1
X-ray repair cross complementing 1.
    
 
 0.947
TDP1
Tyrosyl-DNA phosphodiesterase 1.
    
 
 0.850
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 
 0.838
PARP2
Poly [ADP-ribose] polymerase.
   
 
 0.799
LIG3
DNA ligase.
    
 
 0.791
PNKP
Polynucleotide kinase 3'-phosphatase.
    
 0.773
SETX
Uncharacterized protein.
   
  
 0.739
APLF
Aprataxin and PNKP like factor.
      
 0.737
LIG4
DNA ligase.
    
 
 0.736
SOCS2
Suppressor of cytokine signaling 2.
      
 0.697
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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