Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
ITPR2Ion_trans domain-containing protein. (495 aa)    
Predicted Functional Partners:
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1.
   
 0.931
PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
   
 0.913
PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
   
 0.892
HTT
Huntingtin.
    
 0.882
PRKACB
Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.
    
 0.881
CALML3
Calmodulin like 3; Belongs to the calmodulin family.
    
 0.878
PLCD4
Phosphoinositide phospholipase C.
   
 
 0.865
PLCD3
Phosphoinositide phospholipase C.
   
 
 0.865
ANK3
Ankyrin 3.
    
 0.860
G3UEE5_LOXAF
Uncharacterized protein.
    
 0.860
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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