STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANGPTL4Angiopoietin like 4. (411 aa)    
Predicted Functional Partners:
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
    
 0.981
ANGPTL8
Angiopoietin like 8.
    
 0.967
ANGPTL3
Angiopoietin like 3.
     
0.902
G3UCL2_LOXAF
UPAR/Ly6 domain-containing protein.
   
 
 0.753
VEGFB
Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family.
    
 0.568
CLDN5
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.558
PDGFC
Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.
      
 0.545
SERPINF1
Serpin family F member 1; Belongs to the serpin family.
    
 0.538
CDH5
Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.
   
 
 0.525
TIMP1
TIMP metallopeptidase inhibitor 1.
   
 
 0.499
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.