Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
ZNF516C2H2-type domain-containing protein. (518 aa)    
Predicted Functional Partners:
KDM1A
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
    
 0.936
G3U2E3_LOXAF
Uncharacterized protein.
 
      0.900
PRDM16
PR/SET domain 16.
    
 0.817
G3T5C6_LOXAF
Uncharacterized protein.
    
 0.817
RCOR1
REST corepressor 1.
    
 0.735
ZADH2
Zinc binding alcohol dehydrogenase domain containing 2.
    
 0.731
FRMD6
FERM domain containing 6.
    
 
 0.687
TSHZ1
Teashirt zinc finger homeobox 1.
      
 0.679
CEP70
Centrosomal protein 70.
    
 
 0.677
ZNF407
C2H2-type domain-containing protein.
    
 0.660
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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