MDM2 protein (Loxodonta africana) - STRING interaction network

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MDM2

E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (492 aa)

Predicted Functional Partners:

MDM4

0.997

G3T3Y5_LOXAF

0.993

ATM

0.992

IGF1R

0.992

RB1

0.992

CDKN2B

0.987

USP7

0.979

DAXX

0.977

TP73

0.976

DLG4

0.976

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CDKN2B	ENSLAFP00000006871	ENSLAFP00000016776	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 2B.	0.534
ATM	G3T3Y5_LOXAF	ENSLAFP00000006871	ENSLAFP00000008014	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.517
ATM	MDM2	ENSLAFP00000006871	ENSLAFP00000004935	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.992
ATM	MDM4	ENSLAFP00000006871	ENSLAFP00000001814	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.951
ATM	TP73	ENSLAFP00000006871	ENSLAFP00000005892	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.762
ATM	USP7	ENSLAFP00000006871	ENSLAFP00000006345	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.427
CDKN2B	ATM	ENSLAFP00000016776	ENSLAFP00000006871	Cyclin dependent kinase inhibitor 2B.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.534
CDKN2B	G3T3Y5_LOXAF	ENSLAFP00000016776	ENSLAFP00000008014	Cyclin dependent kinase inhibitor 2B.	Uncharacterized protein.	0.912
CDKN2B	MDM2	ENSLAFP00000016776	ENSLAFP00000004935	Cyclin dependent kinase inhibitor 2B.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.987
CDKN2B	MDM4	ENSLAFP00000016776	ENSLAFP00000001814	Cyclin dependent kinase inhibitor 2B.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.848
CDKN2B	RB1	ENSLAFP00000016776	ENSLAFP00000028512	Cyclin dependent kinase inhibitor 2B.	RB transcriptional corepressor 1.	0.401
DAXX	MDM2	ENSLAFP00000020562	ENSLAFP00000004935	Death domain associated protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.977
DAXX	MDM4	ENSLAFP00000020562	ENSLAFP00000001814	Death domain associated protein.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.836
DAXX	TP73	ENSLAFP00000020562	ENSLAFP00000005892	Death domain associated protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.658
DAXX	USP7	ENSLAFP00000020562	ENSLAFP00000006345	Death domain associated protein.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.993
DLG4	MDM2	ENSLAFP00000015624	ENSLAFP00000004935	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.976
DLG4	MDM4	ENSLAFP00000015624	ENSLAFP00000001814	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.457
G3T3Y5_LOXAF	ATM	ENSLAFP00000008014	ENSLAFP00000006871	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.517
G3T3Y5_LOXAF	CDKN2B	ENSLAFP00000008014	ENSLAFP00000016776	Uncharacterized protein.	Cyclin dependent kinase inhibitor 2B.	0.912
G3T3Y5_LOXAF	MDM2	ENSLAFP00000008014	ENSLAFP00000004935	Uncharacterized protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.993

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