STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KPNA4Importin subunit alpha; Functions in nuclear protein import. (510 aa)    
Predicted Functional Partners:
RELA
RELA proto-oncogene, NF-kB subunit.
    
 0.983
NFKB1
Nuclear factor kappa B subunit 1.
    
 0.968
KPNA3
Importin subunit alpha; Functions in nuclear protein import.
  
0.964
CSE1L
Chromosome segregation 1 like.
   
 0.963
RCC1
Regulator of chromosome condensation 1.
   
 
 0.919
KPNB1
Karyopherin subunit beta 1.
   
 0.908
RANBP3
RAN binding protein 3.
   
 
 0.721
TP53BP1
Tumor protein p53 binding protein 1.
   
   0.693
KDM1A
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
    
   0.690
KPNA1
Importin subunit alpha; Functions in nuclear protein import.
  
0.669
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.