STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMP13Matrix metallopeptidase 13. (471 aa)    
Predicted Functional Partners:
TIMP2
TIMP metallopeptidase inhibitor 2.
   
 0.874
ACAN
Aggrecan.
   
 0.716
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5.
   
 
 0.705
MMP14
Matrix metallopeptidase 14.
  
0.694
TIMP1
TIMP metallopeptidase inhibitor 1.
   
 0.685
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 0.677
MMP16
Matrix metallopeptidase 16.
  
0.676
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif 4.
   
 
 0.673
TIMP3
TIMP metallopeptidase inhibitor 3.
   
 0.672
COL2A1
Collagen type II alpha 1 chain.
   
 0.638
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.