Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)    
Predicted Functional Partners:
IL21R
Interleukin 21 receptor.
  
 0.992
IL2RG
Fibronectin type-III domain-containing protein.
    
 0.979
IL2
Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.
   
 
 0.962
IL15
Interleukin; Belongs to the IL-15/IL-21 family.
  
  
 0.959
IL4
Uncharacterized protein.
   
 
 0.952
JAK3
Tyrosine-protein kinase.
     
 0.931
IL9
Interleukin 9.
   
 
 0.931
IL4R
Interleukin 4 receptor.
  
  
 0.928
TSLP
Uncharacterized protein.
     
 0.918
IL2RA
Interleukin 2 receptor subunit alpha.
   
 
 0.911
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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