B2M protein (Loxodonta africana) - STRING interaction network

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[Homology]

Score

B2M

Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (110 aa)

Predicted Functional Partners:

RPA1

0.974

BLM

0.941

TOP3A

0.933

RMI1

0.927

G3UGQ5_LOXAF

0.907

G3UEZ8_LOXAF

0.900

CD8A

0.885

DNA2

0.880

PDIA3

0.879

PCNA

0.876

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	BLM	ENSLAFP00000005082	ENSLAFP00000007824	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.941
B2M	CD8A	ENSLAFP00000005082	ENSLAFP00000003269	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD8a molecule.	0.885
B2M	DNA2	ENSLAFP00000005082	ENSLAFP00000010850	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA replication helicase/nuclease 2.	0.880
B2M	G3UEZ8_LOXAF	ENSLAFP00000005082	ENSLAFP00000026406	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.900
B2M	G3UGQ5_LOXAF	ENSLAFP00000005082	ENSLAFP00000027013	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.907
B2M	PCNA	ENSLAFP00000005082	ENSLAFP00000005386	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.876
B2M	PDIA3	ENSLAFP00000005082	ENSLAFP00000023403	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Protein disulfide-isomerase.	0.879
B2M	RMI1	ENSLAFP00000005082	ENSLAFP00000021122	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RecQ mediated genome instability 1.	0.927
B2M	RPA1	ENSLAFP00000005082	ENSLAFP00000012864	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.974
B2M	TOP3A	ENSLAFP00000005082	ENSLAFP00000001001	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.933
BLM	B2M	ENSLAFP00000007824	ENSLAFP00000005082	Uncharacterized protein.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.941
BLM	DNA2	ENSLAFP00000007824	ENSLAFP00000010850	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.935
BLM	PCNA	ENSLAFP00000007824	ENSLAFP00000005386	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.787
BLM	RMI1	ENSLAFP00000007824	ENSLAFP00000021122	Uncharacterized protein.	RecQ mediated genome instability 1.	0.996
BLM	RPA1	ENSLAFP00000007824	ENSLAFP00000012864	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.993
BLM	TOP3A	ENSLAFP00000007824	ENSLAFP00000001001	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.997
CD8A	B2M	ENSLAFP00000003269	ENSLAFP00000005082	CD8a molecule.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.885
CD8A	G3UEZ8_LOXAF	ENSLAFP00000003269	ENSLAFP00000026406	CD8a molecule.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.890
CD8A	G3UGQ5_LOXAF	ENSLAFP00000003269	ENSLAFP00000027013	CD8a molecule.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.847
DNA2	B2M	ENSLAFP00000010850	ENSLAFP00000005082	DNA replication helicase/nuclease 2.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.880

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