STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COP1COP1 E3 ubiquitin ligase. (727 aa)    
Predicted Functional Partners:
DET1
Uncharacterized protein.
    
 0.981
DDB2
Damage specific DNA binding protein 2.
    
 0.974
ERCC8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit.
    
  0.950
DDB1
Damage specific DNA binding protein 1.
    
 0.907
RBX1
Ring-box 1.
    
 0.826
CUL4B
Cullin 4B; Belongs to the cullin family.
   
 0.773
CUL4A
Cullin 4A; Belongs to the cullin family.
   
 0.773
DDA1
DET1 and DDB1 associated 1.
    
  0.749
TRIB1
Tribbles pseudokinase 1.
    
 
 0.716
DTL
Denticleless E3 ubiquitin protein ligase homolog.
     
 0.706
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.