STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)    
Predicted Functional Partners:
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
  
 0.882
SLC14A2
Solute carrier family 14 member 2.
   
  
 0.871
AQP11
Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
     
 0.837
CLDN5
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.833
MS4A5
Membrane spanning 4-domains A5.
   
  
 0.753
AQP7
Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
0.729
ACE
Angiotensin-converting enzyme.
   
  
 0.721
AQP3
Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
0.704
AQP8
Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
 
0.695
CFTR
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]
   
 
 0.677
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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