STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCAR1Cell division cycle and apoptosis regulator 1. (1147 aa)    
Predicted Functional Partners:
PRPF40A
Pre-mRNA processing factor 40 homolog A.
   
 0.803
U2SURP
U2 snRNP associated SURP domain containing.
   
  
 0.709
TCERG1
Transcription elongation regulator 1.
   
 
  0.688
DDX50
DExD-box helicase 50.
   
 0.608
CA7
Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family.
      
 0.597
TCERG1L
Transcription elongation regulator 1 like.
   
 
  0.581
G3UGT8_LOXAF
Stork_head domain-containing protein.
 
    
 0.575
TOP1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
   0.558
SIRT5
Sirtuin 5.
    
 0.546
SIRT1
Sirtuin 1.
    
 0.546
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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