Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDC25ACell division cycle 25A. (526 aa)    
Predicted Functional Partners:
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.978
PLK1
Serine/threonine-protein kinase PLK.
   
 0.971
CHEK1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
   
 0.961
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.960
CCNE1
Cyclin E1; Belongs to the cyclin family.
   
 0.958
CHEK2
Checkpoint kinase 2.
   
 0.954
CCNB2
Cyclin B2; Belongs to the cyclin family.
   
 0.953
CCNB1
Cyclin B1; Belongs to the cyclin family.
   
 0.945
CCNE2
Cyclin E2; Belongs to the cyclin family.
   
 0.942
YWHAE
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family.
    
 0.940
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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