Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)    
Predicted Functional Partners:
DLD
Dihydrolipoyl dehydrogenase.
 
 0.997
BCKDHB
Branched chain keto acid dehydrogenase E1 subunit beta.
 
 0.995
BCKDHA
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
 
 0.991
PPM1K
Protein phosphatase, Mg2+/Mn2+ dependent 1K.
    
 0.960
PCCB
Propionyl-CoA carboxylase subunit beta.
  
 
 0.949
IVD
Isovaleryl-CoA dehydrogenase.
   
 0.948
ALDH6A1
Aldehyde dehydrogenase 6 family member A1.
   
 
 0.935
PCCA
Propionyl-CoA carboxylase subunit alpha.
  
 0.932
ECHDC1
Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family.
   
 0.929
HIBADH
3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.
   
 
 0.928
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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