PCNA protein (Loxodonta africana) - STRING interaction network

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PCNA

Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)

Predicted Functional Partners:

RFC4

0.997

CCND1

0.996

RFC3

0.995

RAD18

0.994

LIG1

0.994

GADD45A

0.994

CDK4

0.994

MSH6

0.992

RFC2

0.992

MCM7

0.991

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCND1	CDK4	ENSLAFP00000006453	ENSLAFP00000009022	Cyclin D1; Belongs to the cyclin family.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.999
CCND1	PCNA	ENSLAFP00000006453	ENSLAFP00000005386	Cyclin D1; Belongs to the cyclin family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.996
CDK4	CCND1	ENSLAFP00000009022	ENSLAFP00000006453	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.999
CDK4	GADD45A	ENSLAFP00000009022	ENSLAFP00000007844	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Growth arrest and DNA damage inducible alpha.	0.736
CDK4	MCM7	ENSLAFP00000009022	ENSLAFP00000014468	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.755
CDK4	PCNA	ENSLAFP00000009022	ENSLAFP00000005386	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.994
CDK4	RFC4	ENSLAFP00000009022	ENSLAFP00000020486	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Replication factor C subunit 4.	0.434
GADD45A	CDK4	ENSLAFP00000007844	ENSLAFP00000009022	Growth arrest and DNA damage inducible alpha.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.736
GADD45A	PCNA	ENSLAFP00000007844	ENSLAFP00000005386	Growth arrest and DNA damage inducible alpha.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.994
LIG1	MCM7	ENSLAFP00000007286	ENSLAFP00000014468	DNA ligase.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.751
LIG1	MSH6	ENSLAFP00000007286	ENSLAFP00000001328	DNA ligase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.693
LIG1	PCNA	ENSLAFP00000007286	ENSLAFP00000005386	DNA ligase.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.994
LIG1	RFC2	ENSLAFP00000007286	ENSLAFP00000008863	DNA ligase.	Replication factor C subunit 2.	0.832
LIG1	RFC3	ENSLAFP00000007286	ENSLAFP00000004047	DNA ligase.	Replication factor C subunit 3.	0.902
LIG1	RFC4	ENSLAFP00000007286	ENSLAFP00000020486	DNA ligase.	Replication factor C subunit 4.	0.945
MCM7	CDK4	ENSLAFP00000014468	ENSLAFP00000009022	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.755
MCM7	LIG1	ENSLAFP00000014468	ENSLAFP00000007286	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.751
MCM7	PCNA	ENSLAFP00000014468	ENSLAFP00000005386	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.991
MCM7	RFC2	ENSLAFP00000014468	ENSLAFP00000008863	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication factor C subunit 2.	0.721
MCM7	RFC3	ENSLAFP00000014468	ENSLAFP00000004047	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication factor C subunit 3.	0.899

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