Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (850 aa)    
Predicted Functional Partners:
BCAN
Brevican.
    
 0.949
ACAN
Aggrecan.
    
 0.943
G3UGB1_LOXAF
GON domain-containing protein.
 
  
 0.927
MMP13
Matrix metallopeptidase 13.
    
 
 0.762
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif 15.
    
 0.761
ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif 8.
   
 0.738
COL2A1
Collagen type II alpha 1 chain.
    
 0.608
ADAMTS19
PLAC domain-containing protein.
 
  
 0.572
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1.
    
 0.560
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
      
 0.546
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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