TPK1 protein (Loxodonta africana) - STRING interaction network

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Score

TPK1

Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (242 aa)

Predicted Functional Partners:

THTPA

0.939

AK5

0.909

AK7

0.886

AK2

0.877

AK4

0.877

AK8

0.877

NTPCR

0.872

ALPI

0.870

ALPL

0.870

G3TM24_LOXAF

0.851

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK2	AK4	ENSLAFP00000004402	ENSLAFP00000006788	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	0.871
AK2	AK5	ENSLAFP00000004402	ENSLAFP00000009517	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.901
AK2	AK7	ENSLAFP00000004402	ENSLAFP00000020556	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Adenylate kinase 7.	0.907
AK2	AK8	ENSLAFP00000004402	ENSLAFP00000012902	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.909
AK2	G3TM24_LOXAF	ENSLAFP00000004402	ENSLAFP00000016094	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.843
AK2	NTPCR	ENSLAFP00000004402	ENSLAFP00000017065	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Nucleoside-triphosphatase, cancer-related.	0.969
AK2	THTPA	ENSLAFP00000004402	ENSLAFP00000002658	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP).	0.874
AK2	TPK1	ENSLAFP00000004402	ENSLAFP00000005422	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.877
AK4	AK2	ENSLAFP00000006788	ENSLAFP00000004402	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.871
AK4	AK5	ENSLAFP00000006788	ENSLAFP00000009517	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.925
AK4	AK7	ENSLAFP00000006788	ENSLAFP00000020556	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Adenylate kinase 7.	0.919
AK4	AK8	ENSLAFP00000006788	ENSLAFP00000012902	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.875
AK4	G3TM24_LOXAF	ENSLAFP00000006788	ENSLAFP00000016094	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.847
AK4	NTPCR	ENSLAFP00000006788	ENSLAFP00000017065	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Nucleoside-triphosphatase, cancer-related.	0.878
AK4	THTPA	ENSLAFP00000006788	ENSLAFP00000002658	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP).	0.874
AK4	TPK1	ENSLAFP00000006788	ENSLAFP00000005422	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.877
AK5	AK2	ENSLAFP00000009517	ENSLAFP00000004402	Adenylate kinase 5; Belongs to the adenylate kinase family.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.901
AK5	AK4	ENSLAFP00000009517	ENSLAFP00000006788	Adenylate kinase 5; Belongs to the adenylate kinase family.	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	0.925
AK5	AK7	ENSLAFP00000009517	ENSLAFP00000020556	Adenylate kinase 5; Belongs to the adenylate kinase family.	Adenylate kinase 7.	0.955
AK5	AK8	ENSLAFP00000009517	ENSLAFP00000012902	Adenylate kinase 5; Belongs to the adenylate kinase family.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.909

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