STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (487 aa)    
Predicted Functional Partners:
JUN
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
   
 0.996
CREBBP
CREB binding protein.
   
 0.993
CREB5
Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription.
    
  0.990
MAPK14
Mitogen-activated protein kinase.
    
 0.981
MAPK9
Mitogen-activated protein kinase.
   
 0.970
MAPK13
Mitogen-activated protein kinase.
    
 0.959
MAPK1
Mitogen-activated protein kinase.
   
 0.955
EP300
E1A binding protein p300.
   
 0.954
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit.
   
 0.954
MAPK12
Mitogen-activated protein kinase.
    
 0.951
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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