Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)    
Predicted Functional Partners:
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
   
 0.970
MAP3K1
Mitogen-activated protein kinase kinase kinase 1.
    
 0.945
ARAF
A-Raf proto-oncogene, serine/threonine kinase.
   
 0.944
LAMTOR3
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3.
   
 0.936
KRAS
KRAS proto-oncogene, GTPase.
   
 0.916
MAPK12
Mitogen-activated protein kinase.
   
 0.913
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
   
 0.910
MAPK1
Mitogen-activated protein kinase.
   
 0.908
MAPK3
Mitogen-activated protein kinase.
   
 0.908
MAP3K8
Mitogen-activated protein kinase kinase kinase 8.
   
 0.906
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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