STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRDM5Zinc finger protein. (599 aa)    
Predicted Functional Partners:
UROS
Uroporphyrinogen III synthase.
    
 
 0.738
EDIL3
EGF like repeats and discoidin domains 3.
    
 
 0.668
PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]
    
 0.625
PCOLCE2
Procollagen C-endopeptidase enhancer 2.
      
 0.594
SETD2
SET domain containing 2, histone lysine methyltransferase.
   
 0.582
KMT5A
Lysine methyltransferase 5A.
   
 0.558
PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.
   
 
 0.553
ADAM23
ADAM metallopeptidase domain 23.
     
 0.547
ZNF644
Zinc finger protein 644.
    
 0.535
SH3RF3
SH3 domain containing ring finger 3.
   
 0.534
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.