Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)    
Predicted Functional Partners:
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
 
 
 0.994
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
 
 
 0.986
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
 
 
 0.964
PKIA
cAMP-dependent protein kinase inhibitor; Belongs to the PKI family.
   
 0.961
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
 
 
 0.961
RYR2
Ryanodine receptor 2.
    
 0.937
CREB1
cAMP responsive element binding protein 1.
    
 0.937
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.935
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.934
BAD
BCL2 associated agonist of cell death.
   
 0.922
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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