Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TBX4T-box transcription factor 4. (553 aa)    
Predicted Functional Partners:
NKX2-5
NK2 homeobox 5.
   
 0.856
MGA
MAX dimerization protein MGA.
 
      0.825
BDNF
Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
      
 0.747
G3SMI1_LOXAF
Uncharacterized protein.
      
 0.737
EIF2AK4
Eukaryotic translation initiation factor 2 alpha kinase 4.
      
 0.668
HAND2
Heart and neural crest derivatives expressed 2.
    
 0.651
HOXC10
Homeobox C10.
    
 
 0.636
SOX30
SRY-box transcription factor 30.
    
 0.621
PITX1
Homeobox protein.
    
 
 0.603
ATP7B
ATPase copper transporting beta.
   
  
 0.602
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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