STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AVENApoptosis and caspase activation inhibitor. (265 aa)    
Predicted Functional Partners:
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.982
BCL2L1
BCL2 like 1.
    
 
 0.659
RPL39
Uncharacterized protein.
      
 0.646
PACS2
Phosphofurin acidic cluster sorting protein 2.
      
 0.624
WTIP
WT1 interacting protein.
      
 0.597
TTC7B
Uncharacterized protein.
      
 0.578
SEC63
SEC63 homolog, protein translocation regulator.
      
 0.538
CASP9
Caspase 9; Belongs to the peptidase C14A family.
     
 0.515
TPX2
TPX2 microtubule nucleation factor.
    
 0.509
CSTB
Cystatin B; Belongs to the cystatin family.
    
 0.509
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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