STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
G3SYI0_LOXAFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (660 aa)    
Predicted Functional Partners:
ERBB2
Receptor protein-tyrosine kinase.
   
 0.912
ERBB4
GF_recep_IV domain-containing protein.
 
      0.900
NRG1
Neuregulin 1.
    
 0.894
GRB2
Growth factor receptor bound protein 2.
    
 0.885
NRG2
Neuregulin 2.
    
 0.877
EGFR
Receptor protein-tyrosine kinase.
    
 0.870
NRG4
Neuregulin 4.
    
 0.870
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
   
 0.859
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.855
EREG
Epiregulin.
    
 0.845
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (12%) [HD]