Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
TBK1TANK binding kinase 1. (730 aa)    
Predicted Functional Partners:
IRF3
IRF tryptophan pentad repeat domain-containing protein.
    
 0.998
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.997
STING1
Transmembrane protein 173.
   
 0.996
TANK
TRAF family member associated NFKB activator.
   
 0.996
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
   
 0.995
SQSTM1
Sequestosome 1.
    
 0.994
CALCOCO2
Calcium binding and coiled-coil domain 2.
    
 0.993
MAVS
Mitochondrial antiviral signaling protein.
    
 0.986
EXOC2
Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.
   
 0.985
RELA
RELA proto-oncogene, NF-kB subunit.
   
 0.979
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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