Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
MST1RMacrophage stimulating 1 receptor. (1386 aa)    
Predicted Functional Partners:
MST1
Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.994
GRB2
Growth factor receptor bound protein 2.
    
 0.944
GAB1
GRB2 associated binding protein 1.
    
 0.938
FRK
Tyrosine-protein kinase.
   
  0.932
CBL
Cbl proto-oncogene.
    
 0.920
HGF
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 0.911
G3U7P9_LOXAF
Uncharacterized protein.
    
 0.911
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    
 0.907
FGF5
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
  
 
 0.906
PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
   
 0.903
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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