STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (228 aa)    
Predicted Functional Partners:
UFD1
Ubiquitin recognition factor in ER associated degradation 1.
   
 
 0.895
SEL1L
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 0.889
OS9
OS9 endoplasmic reticulum lectin.
    
 0.883
SYVN1
Synoviolin 1.
   
 0.875
DERL1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
0.873
ERLEC1
Endoplasmic reticulum lectin 1.
    
 0.865
AMFR
Autocrine motility factor receptor.
   
 0.859
SEL1L2
SEL1L2 adaptor subunit of ERAD E3 ligase.
   
 0.837
VCP
Valosin containing protein; Belongs to the AAA ATPase family.
   
 0.831
ERGIC2
ERGIC and golgi 2.
   
 
 0.819
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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