ESD protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ESD

S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)

Predicted Functional Partners:

G3TRI1_LOXAF

0.955

G3UMJ2_LOXAF

0.949

ADH6

0.938

ADH5

0.935

G3T2A7_LOXAF

0.913

G3TZW9_LOXAF

0.913

FSD2

0.826

SORD

0.782

GLO1

0.711

G3U1V7_LOXAF

0.625

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH5	ESD	ENSLAFP00000000841	ENSLAFP00000005796	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.935
ADH6	ESD	ENSLAFP00000011030	ENSLAFP00000005796	Alcohol dehydrogenase 6 (class V).	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.938
ESD	ADH5	ENSLAFP00000005796	ENSLAFP00000000841	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.935
ESD	ADH6	ENSLAFP00000005796	ENSLAFP00000011030	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Alcohol dehydrogenase 6 (class V).	0.938
ESD	FSD2	ENSLAFP00000005796	ENSLAFP00000006780	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Fibronectin type III and SPRY domain containing 2.	0.826
ESD	G3T2A7_LOXAF	ENSLAFP00000005796	ENSLAFP00000007290	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	ADH_zinc_N domain-containing protein.	0.913
ESD	G3TRI1_LOXAF	ENSLAFP00000005796	ENSLAFP00000018189	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	PKS_ER domain-containing protein.	0.955
ESD	G3TZW9_LOXAF	ENSLAFP00000005796	ENSLAFP00000021127	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein.	0.913
ESD	G3U1V7_LOXAF	ENSLAFP00000005796	ENSLAFP00000021815	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.625
ESD	G3UMJ2_LOXAF	ENSLAFP00000005796	ENSLAFP00000029051	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	PKS_ER domain-containing protein.	0.949
ESD	GLO1	ENSLAFP00000005796	ENSLAFP00000008705	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	0.711
ESD	SORD	ENSLAFP00000005796	ENSLAFP00000026098	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Sorbitol dehydrogenase.	0.782
FSD2	ESD	ENSLAFP00000006780	ENSLAFP00000005796	Fibronectin type III and SPRY domain containing 2.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.826
G3T2A7_LOXAF	ESD	ENSLAFP00000007290	ENSLAFP00000005796	ADH_zinc_N domain-containing protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.913
G3TRI1_LOXAF	ESD	ENSLAFP00000018189	ENSLAFP00000005796	PKS_ER domain-containing protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.955
G3TZW9_LOXAF	ESD	ENSLAFP00000021127	ENSLAFP00000005796	Uncharacterized protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.913
G3U1V7_LOXAF	ESD	ENSLAFP00000021815	ENSLAFP00000005796	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.625
G3U1V7_LOXAF	GLO1	ENSLAFP00000021815	ENSLAFP00000008705	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	0.836
G3U1V7_LOXAF	SORD	ENSLAFP00000021815	ENSLAFP00000026098	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Sorbitol dehydrogenase.	0.516
G3UMJ2_LOXAF	ESD	ENSLAFP00000029051	ENSLAFP00000005796	PKS_ER domain-containing protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.949

page 1 of 2

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Co-occurrence

Textmining

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About