Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SLC7A14Solute carrier family 7 member 14. (771 aa)    
Predicted Functional Partners:
RPL22L1
Ribosomal protein L22 like 1.
      
 0.635
RHBDD2
Rhomboid domain containing 2.
      
 0.535
AGBL5
ATP/GTP binding protein like 5.
    
 
 0.511
FAM102B
Family with sequence similarity 102 member B.
      
 0.491
RPL22
Uncharacterized protein.
      
 0.490
GAPT
GRB2 binding adaptor protein, transmembrane.
      
 0.485
MST1R
Macrophage stimulating 1 receptor.
    
  0.446
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
  0.446
MEDAG
Mesenteric estrogen dependent adipogenesis.
      
 0.411
PCSK2
Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.
   
 
 0.411
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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