Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GIT2GIT ArfGAP 2. (760 aa)    
Predicted Functional Partners:
GIT1
GIT ArfGAP 1.
   
  0.983
LPXN
Leupaxin.
    
 0.947
PXN
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
    
 0.947
CDC42
Uncharacterized protein.
    
 0.942
ARHGEF7
Rho guanine nucleotide exchange factor 7.
   
 0.932
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
   
 0.932
PAK3
Non-specific serine/threonine protein kinase.
    
 0.901
PAK1
Non-specific serine/threonine protein kinase.
    
 0.901
PAK2
Non-specific serine/threonine protein kinase.
    
 0.846
CAMK4
Calcium/calmodulin dependent protein kinase IV.
   
 0.821
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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