STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRAP2GRB2 related adaptor protein 2. (327 aa)    
Predicted Functional Partners:
LCP2
Lymphocyte cytosolic protein 2.
   
 0.999
ITSN2
Intersectin 2.
     
0.952
G3U095_LOXAF
Uncharacterized protein.
     
 0.952
LAT
Linker for activation of T cells.
   
 0.927
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
    
 0.903
PTPN23
Protein tyrosine phosphatase non-receptor type 23.
   
 0.880
MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
   
 
 0.876
GRB2
Growth factor receptor bound protein 2.
  
 
0.858
VAV1
Vav guanine nucleotide exchange factor 1.
    
0.850
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.827
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.