STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTCH1Patched 1. (1438 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.993
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.983
SHH
Sonic hedgehog signaling molecule.
   
 0.983
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.980
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.963
CDON
Cell adhesion associated, oncogene regulated.
    
 0.954
GLI3
GLI family zinc finger 3.
   
 0.929
SMURF2
E3 ubiquitin-protein ligase.
    
 0.923
SMURF1
E3 ubiquitin-protein ligase.
    
 0.923
GLI2
GLI family zinc finger 2.
   
 0.904
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.