Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SMCO4Single-pass membrane protein with coiled-coil domains 4. (59 aa)    
Predicted Functional Partners:
VSTM5
V-set and transmembrane domain containing 5.
      
 0.674
PDZD11
PDZ domain containing 11.
      
 0.518
C11orf54
Chromosome 11 open reading frame 54.
      
 0.497
G3U536_LOXAF
Uncharacterized protein.
      
 0.494
HEPHL1
Hephaestin like 1.
      
 0.485
F2RL2
Coagulation factor II thrombin receptor like 2.
      
 0.479
NUDT6
Nudix hydrolase domain-containing protein.
      
 0.445
MED17
Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.417
GALNT5
Polypeptide N-acetylgalactosaminyltransferase.
      
 0.413
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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